<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Custódio, Luísa</style></author><author><style face="normal" font="default" size="100%">Patarra, João</style></author><author><style face="normal" font="default" size="100%">Alberício, Fernando</style></author><author><style face="normal" font="default" size="100%">Neng, Nuno Rosa</style></author><author><style face="normal" font="default" size="100%">Nogueira, José Manuel Florêncio</style></author><author><style face="normal" font="default" size="100%">Romano, Anabela</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Extracts from Quercus sp. acorns exhibit in vitro neuroprotective features through inhibition of cholinesterase and protection of the human dopaminergic cell line SH-SY5Y from hydrogen peroxide-induced cytotoxicity</style></title><secondary-title><style face="normal" font="default" size="100%">Industrial Crops and Products</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">acorns</style></keyword><keyword><style  face="normal" font="default" size="100%">Alzheimer's</style></keyword><keyword><style  face="normal" font="default" size="100%">Cholinesterase</style></keyword><keyword><style  face="normal" font="default" size="100%">Dementia</style></keyword><keyword><style  face="normal" font="default" size="100%">Mediterranean trees</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurological disorders</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2013///</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0926669012006450</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">45</style></volume><pages><style face="normal" font="default" size="100%">114 - 120</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">In this work non polar (hexane) and polar (methanol and hot water) extracts of cork oak (Quercus suber) and holm oak (Quercus ilex) acorns were evaluated for the first time for in vitro neuroprotective properties, by determining their in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) and their capacity to attenuate hydrogen peroxide-induced injury in the human dopaminergic cell line SH-SY5Y. Total content of phenolics, tannins and flavonoids, HPLC profile of the main phenolic compounds and antioxidant activity were also determined. The methanol extracts showed inhibitory activities against AChE and BChE. The best results toward AChE were obtained with cork oak extract (69.4% inhibition at the concentration of 1 mg/ml), while for BChE the highest inhibition (46% inhibition at the concentration of 1 mg/ml) was obtained with holm oak. Moreover, methanol extracts were able to prevent oxidative stress-induced cytotoxicity in SH-S5SY cells. The methanol extract of holm oak exhibited the highest RSA, with values of 63.8% and 49.7% on DPPH and ABTS radicals at the concentration of 1 mg/ml, respectively. In general the extracts exhibited no reducing potential. The methanol extract from cork oak acorns had the highest content in phenolic compounds (25.2 mg GAE/g, DW), while the water extracts had the maximum level of flavonoids (1.7 mg RE/g, DW). Tannins were present in higher amounts in the water extract of holm oak (91.6 CE/g, DW). The main compounds in the methanol extract from holm oak acorns were (−)-epicatechin and catechol, while gallic acid and (+)-catechin were the main constituents of the methanol extract from cork oak acorns. Our results indicate that cork and holm oak acorns provide a valuable source of biomolecules useful for alleviating symptoms associated with Alzheimer's disease and other neurodegenerative ailments.</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tognetti, Roberto</style></author><author><style face="normal" font="default" size="100%">Cherubini, Paolo</style></author><author><style face="normal" font="default" size="100%">INNES, JOHN L.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative stem-growth rates of Mediterranean trees under background and naturally enhanced ambient CO2 concentrations</style></title><secondary-title><style face="normal" font="default" size="100%">New Phytologist</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Arbutus unedo (strawberry tree)</style></keyword><keyword><style  face="normal" font="default" size="100%">Carbon Sequestration</style></keyword><keyword><style  face="normal" font="default" size="100%">Dendroecology</style></keyword><keyword><style  face="normal" font="default" size="100%">Mediterranean trees</style></keyword><keyword><style  face="normal" font="default" size="100%">natural CO2 springs</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercus ilex (holm oak)</style></keyword><keyword><style  face="normal" font="default" size="100%">tree rings</style></keyword><keyword><style  face="normal" font="default" size="100%">water stress</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2000</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2000///</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1046/j.1469-8137.2000.00620.x</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">146</style></volume><pages><style face="normal" font="default" size="100%">59 - 74</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Ring widths of five Mediterranean forest tree species (Arbutus unedo, Fraxinus ornus, Quercus cerris, Quercus ilex and Quercus pubescens) growing close to a natural source of CO2 in Tuscany, Italy and at a nearby control site were compared. At the CO2-enriched site, trees have been growing for decades under elevated CO2 concentrations. They originated from parent trees that also grew under elevated CO2 in natural conditions, and they have been continuously exposed to elevated CO2 throughout their growth. Tree-ring series from each of the species were prepared. Assigning calendar dates to rings was difficult but possible, and ring-width series were built for all species. The ring-width data were analysed using a two-sided t-test to assess if there was a difference between the radial growth at the CO2-enriched site and the control site. The cumulative basal area at the same cambial age at both sites was also compared using a Wilcoxon test. Radial growth of trees at the CO2-enriched site was not significantly different from growth at the control site. For each species, year by year, radial growth at the CO2-enriched site was tested against the control site and significant differences were found in only a few years; these differences were not synchronous with extreme climatic events. The expected increase in above-ground productivity, as one of the ecosystem responses to increasing CO2 during drought stress, was not observed in this Mediterranean woody plant community, despite being water-limited. Other resource limitations, such as low nutrient availability (common in the Mediterranean region), may have counteracted the positive effect of elevated CO2 under drought stress, or trees may have acclimated to the high CO2.</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><notes><style face="normal" font="default" size="100%">The following values have no corresponding Zotero field:&lt;br/&gt;publisher: Cambridge University Press</style></notes></record></records></xml>